GHRP-6

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide examined in controlled laboratory research for its ability to promote endogenous growth hormone release via activation of the ghrelin receptor (GHS-R1a). Research explores its potential roles in appetite stimulation, metabolic regulation, tissue repair, modulation of body composition, and inflammatory response pathways. This compound is intended solely for in vitro research and is not approved for diagnostic, therapeutic, veterinary, or human use.

For laboratory research use only. Not for human or veterinary use. Not intended for diagnostic, therapeutic, or clinical applications.

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GHRP-6

Form: Scientific-grade, Lyophilized Powder

Purity: ≥99%

CAS Number: 145177-42-0

GHRP-6 (Growth Hormone Releasing Peptide-6) is a research-use-only synthetic hexapeptide studied for its influence on growth hormone release, metabolic function, and tissue repair via ghrelin receptor pathways. It is strictly intended for in vitro laboratory research only.

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Chemical Structure & Identifiers

PubChem CID: 4345065 Structure: Hexapeptide: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ Molecular Formula: C₄₆H₅₆N₁₂O₆ Synonyms: GHRP-6, Growth Hormone Releasing Peptide-6, GH-Releasing Hexapeptide CAS Number: 87616-84-0 Molecular Weight: 873.01 g/mol Computed by PubChem: (PubChem release 2021.10.14) Date Created: 2005-07-27 Last Modified: 2025-07-28

GHRP-6 is provided for qualified research involving growth hormone secretagogue activity, ghrelin receptor pathways, metabolic signaling, and endocrine modulation. It is not approved for clinical, diagnostic, or human consumption. Research-use only.

Mechanism of Action

GHRP-6 is a synthetic hexapeptide and potent growth hormone secretagogue that activates the ghrelin receptor (GHS-R1a). It stimulates the hypothalamic-pituitary axis, resulting in pulsatile release of growth hormone (GH) from the anterior pituitary.

Ghrelin Receptor Activation: GHRP-6 mimics the action of ghrelin, the endogenous ligand of the GHS-R1a receptor, leading to significant GH release.
Increased IGF-1 Production: The rise in GH can lead to elevated levels of insulin-like growth factor 1 (IGF-1), influencing cellular repair and anabolism in muscle and other tissues.
Metabolic Effects: Research has examined GHRP-6’s role in modulating fat metabolism, insulin sensitivity, and body composition due to the downstream effects of GH and IGF-1.
Appetite Stimulation: GHRP-6 is known to significantly stimulate appetite via hypothalamic pathways, a property of interest in catabolic or wasting conditions.
Anti-Inflammatory Potential: Preliminary studies suggest GHRP-6 may influence cytokine profiles and support anti-inflammatory responses through GH and ghrelin pathways.

These mechanisms make GHRP-6 a key molecule for investigating endocrine signaling, appetite regulation, tissue repair, and metabolic modulation in preclinical research settings.

Clinical Development & Research Focus

GHRP-6 has been extensively studied in animal and cell-based models for its effects on the GH/IGF-1 axis, metabolic health, and tissue regeneration. Although not FDA-approved for clinical use, it remains a valuable tool in experimental endocrinology.

Growth Hormone Secretion Studies: Animal studies confirm GHRP-6’s ability to elicit robust GH release and enhance IGF-1 signaling.
Muscle and Cartilage Repair: Research investigates GHRP-6 for its anabolic effects and potential applications in skeletal muscle and joint regeneration.
Gastrointestinal Recovery: Some models suggest a role in improving intestinal barrier integrity and healing post-injury, attributed to GH and ghrelin pathways.
Inflammatory Modulation: GHRP-6 has shown the ability to influence inflammatory markers, making it relevant for models studying immune system balance and healing.
Appetite and Cachexia: Its orexigenic properties are useful in animal models studying anorexia, cachexia, and metabolic wasting disorders.

Despite promising outcomes in early-phase research, GHRP-6 remains classified as a research chemical and has not undergone regulatory approval for therapeutic use.

Guidelines for Experimental Use

GHRP-6 is provided strictly for scientific research purposes only. It must be handled by qualified laboratory personnel in facilities equipped for chemical and biological experimentation. The compound is not approved for human or veterinary use. It is not intended for diagnostic or therapeutic applications. Appropriate safety protocols—including the use of personal protective equipment (PPE), proper containment, and adherence to institutional research guidelines—must be observed at all times.

Key Scientific References

For deeper insights into the mechanisms and applications of GHRP-6, refer to the following key publications:

Important Compliance Statement

This compound, GHRP-6, is offered exclusively for use in laboratory research and development. It is not intended for use as a pharmaceutical, food additive, cosmetic, or household chemical. It has not been evaluated by any regulatory authority for safety or efficacy. By purchasing or using this product, researchers agree to conduct all experiments in compliance with local, national, and international regulations. Any misuse—including administration to humans or animals—is strictly prohibited.

Analytical Validation & Documentation (COA, HPLC, MS)

Each production lot is subjected to rigorous analytical validation to confirm quality, purity, and molecular identity under research-grade standards. Full supporting documentation is available upon request.

COA (Certificate of Analysis): Includes batch number, purity percentage, traceability of each constituent ingredient, storage instructions, and full QC test results.
HPLC (High-Performance Liquid Chromatography): Provides chromatographic confirmation of purity and compound homogeneity.
MS (Mass Spectrometry): Confirms molecular weight and verifies structural integrity of the compound.
Traceability: Documents are traceable to their respective manufacturing lot and are intended to support reproducibility and transparency in scientific investigation.

Displayed above: Sample Certificate of Analysis – AOD-9604 (3-page image preview)

Storage & Shipping

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures stability during transit and long-term storage. Below are the official recommendations:

Stability During Shipping: Products are 100% stable for shipping for up to 3–4 months at ambient temperature.
After Reconstitution: Once reconstituted with bacteriostatic water, the peptide must be stored in a refrigerator and will remain stable for up to 30 days.
Room Temperature Storage: Lyophilized powder can be safely stored at room temperature until reconstitution, provided it remains sealed and protected from light.
Refrigerated Storage (Short Term): Store under 4°C (39°F) if not used immediately. Suitable for storage up to several weeks or months.
Frozen Storage (Long Term): For extended stability (months to years), store in a freezer at -80°C (-112°F).

Note: Avoid repeated freeze-thaw cycles. Always aliquot after reconstitution when necessary. Follow institutional safety protocols for handling all research compounds.

For advanced storage tips and reconstitution guidance, contact us or refer to our extended documentation.

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