Gonadorelin
Gonadorelin is a synthetic decapeptide identical in amino acid sequence to endogenous gonadotropin-releasing hormone (GnRH), a hypothalamic neuropeptide responsible for initiating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. In controlled research settings, it is used to model and analyze hypothalamic–pituitary–gonadal (HPG) axis signaling, receptor binding kinetics, and endocrine feedback mechanisms. This material is supplied exclusively for qualified in vitro laboratory research and is not intended for human or veterinary administration, diagnosis, or therapeutic application.
For laboratory research use only. Not for human or veterinary use. Not intended for diagnostic, therapeutic, or clinical applications.
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Gonadorelin
Form: Scientific-grade, Lyophilized Powder
Purity: ≥99%
CAS Number: 33515-09-2
Gonadorelin is a synthetic decapeptide used in scientific investigations of GnRH-related hormone pathways. This material is provided for research use only and is not for human or veterinary use.
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Chemical Structure & Identifiers
Gonadorelin is a synthetic decapeptide mimicking natural GnRH, often studied in endocrine and reproductive signaling research. Provided strictly for in vitro laboratory experimentation. Not for human or veterinary use.
Research Applications of Gonadorelin
Gonadorelin is a synthetic decapeptide identical to endogenous **gonadotropin-releasing hormone (GnRH)**, a critical regulator of the reproductive endocrine system. Its primary research applications include:
- Hormone Regulation Studies: Used to investigate the mechanisms by which GnRH stimulates the pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland.
- Reproductive Physiology: Employed in research to understand the complex interplay of hormones in the reproductive axis, including puberty, menstrual cycles, and spermatogenesis.
- Infertility Research: Utilized in preclinical models to explore potential diagnostic and therapeutic strategies for various reproductive disorders linked to GnRH deficiency or dysregulation.
- Veterinary Research: Applied in animal models to study reproductive management and breeding protocols.
It is important to note that while preclinical evidence is strong and diverse, Gonadorelin remains an **investigational research chemical**. Its use outside of controlled research settings is not approved by regulatory bodies for any therapeutic use in humans or animals.
Guidelines for Experimental Use
Gonadorelin is strictly intended for **laboratory research purposes only**. It must be handled by qualified research personnel in a controlled laboratory environment, adhering to all applicable safety protocols and guidelines for investigational research chemicals. This product is **not approved for human consumption, therapeutic use, or veterinary applications**. Its use is limited to scientific investigation and analysis. Proper laboratory safety equipment, including personal protective equipment (PPE), and procedures must be employed during its handling, storage, and experimental application. Researchers should consult relevant safety data sheets (SDS) and institutional guidelines before use.
Storage and Handling Recommendations
For optimal stability and preservation of Gonadorelin, observe the following recommendations:
- Storage: Store lyophilized powder at -20°C to -80°C (long-term) or 2°C to 8°C (short-term, for up to 2-4 weeks), away from light and moisture.
- Reconstitution: Reconstitute with sterile, deionized water or a suitable solvent as per specific experimental protocols. Avoid repeated freeze-thaw cycles.
- Handling: Handle under aseptic conditions to prevent contamination. Use appropriate personal protective equipment (PPE), including gloves and eye protection.
- Stability: Once reconstituted, solutions should be stored at 2°C to 8°C and used within a short period, typically 24-72 hours, depending on the solvent and concentration. Long-term storage of reconstituted solutions is not recommended.
- Disposal: Dispose of Gonadorelin and any waste materials in accordance with local and institutional hazardous waste regulations.
Strict adherence to these guidelines will help maintain the integrity and purity of the compound for research applications.
Key Scientific References
For more detailed information on Gonadorelin and its research applications, please refer to the following scientific literature and review articles, primarily from preclinical studies:
- Clinical use of gonadorelin (1983)
- Gonadorelin: a synthetic gonadotropin-releasing hormone (1981)
- Pulsatile administration of gonadorelin for induction of ovulation in women with hypothalamic amenorrhoea (1991)
- Gonadorelin as a probe of anterior pituitary function: current status (1988)
- PubChem Compound Summary: Gonadorelin (CID 638793)
*(Note: References are primarily focused on preclinical and mechanistic studies, reflecting Gonadorelin's status as a research compound.)*
Important Compliance Statement
This product, Gonadorelin, is sold exclusively for **research and development purposes**. It is classified as a research chemical and is **not a drug, food, or cosmetic**. It has not been evaluated or approved by the FDA or any other regulatory authority for safety, efficacy, or any other use in humans or animals. By purchasing this product, the user acknowledges and agrees to comply with all applicable local, national, and international laws and regulations regarding the handling, storage, and use of research compounds. Any use of this product for purposes other than legitimate scientific research is strictly prohibited and may lead to severe legal and health consequences.
Analytical Validation & Documentation (COA, HPLC, MS)
Each production lot is subjected to rigorous analytical validation to confirm quality, purity, and molecular identity under research-grade standards. Full supporting documentation is available upon request.
- COA (Certificate of Analysis): Includes batch number, purity percentage, traceability of each constituent ingredient, storage instructions, and full QC test results.
- HPLC (High-Performance Liquid Chromatography): Provides chromatographic confirmation of purity and compound homogeneity.
- MS (Mass Spectrometry): Confirms molecular weight and verifies structural integrity of the compound.
- Traceability: Documents are traceable to their respective manufacturing lot and are intended to support reproducibility and transparency in scientific investigation.
Displayed above: Sample Certificate of Analysis – AOD-9604 (3-page image preview)
Storage & Shipping
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures stability during transit and long-term storage. Below are the official recommendations:
- Stability During Shipping: Products are 100% stable for shipping for up to 3–4 months at ambient temperature.
- After Reconstitution: Once reconstituted with bacteriostatic water, the peptide must be stored in a refrigerator and will remain stable for up to 30 days.
- Room Temperature Storage: Lyophilized powder can be safely stored at room temperature until reconstitution, provided it remains sealed and protected from light.
- Refrigerated Storage (Short Term): Store under 4°C (39°F) if not used immediately. Suitable for storage up to several weeks or months.
- Frozen Storage (Long Term): For extended stability (months to years), store in a freezer at -80°C (-112°F).
Note: Avoid repeated freeze-thaw cycles. Always aliquot after reconstitution when necessary. Follow institutional safety protocols for handling all research compounds.
For advanced storage tips and reconstitution guidance, contact us or refer to our extended documentation.